The human protein atlas (HPA) is a large, digitally-colored image that displays all known information about the proteins in the human body. Being completely visual and interactive, the HPA opens up new possibilities for studying the human proteome with data presented visually rather than in tabular form. The Human Protein Atlas (HPA) is a project to systematically map biosignatures of all major elements in the human proteome, with an emphasis on tissue complexes and their interactions.
The human protein atlas initiative is a Swedish initiative, launched in 2003
It aims to produce a comprehensive picture of all the proteins in the human body. The idea is to map all proteins in the human body and their interactions with each other. This will provide a snapshot of how the human body functions, and could be used to detect diseases early on.
The goal of the project is to map all the proteins expressed in the human body
The Human Protein Atlas is an initiative to map the human proteome. The project is a collaboration of the European Bioinformatics Institute, EMBL-EBI, Welcome Trust Sanger Institute and several other organizations.
The goal of the project is to map all the proteins expressed in the human body. This will allow researchers to study how proteins are distributed throughout the body and how they interact with each other.
The Human Protein Atlas has been running since 2005, when it was launched as part of the Human Proteome Project (HUPO). The HUPO project aims to identify all human proteins, characterize their interactions and functions, and determine how these proteins are affected by disease states.
What does it mean for a protein to be expressed? When a gene is turned on (expressed) during development or under certain conditions in an adult, it produces RNA molecules called messenger RNA (mRNA).
These mRNA molecules then travel out of cells through their cell membranes into the bloodstream where they can be used by other cells. The mRNA travels through capillaries until it reaches a liver cell or another type of cell that can read its genetic information and turn it into protein molecules.
There are 20,000 distinct genes in humans
The Human Protein Atlas (HPAtlas) is a global effort to map all protein interactions in the human body. The HPAtlas is a collaborative project between scientists at Harvard Medical School, MIT, Stanford University and the Broad Institute of MIT and Harvard.
The Human Protein Atlas (HPAtlas) is a global effort to map all protein interactions in the human body. The HPAtlas is a collaborative project between scientists at Harvard Medical School, MIT, Stanford University and the Broad Institute of MIT and Harvard. The project uses mass spectrometry to map proteins in human cells from various tissues.
There are 20,000 distinct genes in humans. Each gene produces one or more proteins that perform many different functions throughout our bodies. Proteins interact with other proteins inside cells and also with molecules outside cells to regulate how our bodies function as well as determine how we respond to disease or injury.
The Atlas as open science resource
The Human Protein Atlas is an open-access resource that aims to help researchers and clinicians better understand the human proteome. It includes an interactive map of all proteins in the human body, as well as detailed information on each protein’s function, location in the body, and links to related research.
The Human Protein Atlas has been built using data from over 7,000 scientific papers and other sources, including the NCBI Gene Expression Omnibus databank. This large body of data has been assembled by experts in different fields, who have each contributed their own knowledge to build a comprehensive picture of human biology.
If a protein is not expressed, no function can be attributed to it
The human protein atlas is the most comprehensive resource of human protein expression data. It provides access to the most recent data on more than 20,000 differentially expressed proteins in various conditions, including tissue types, diseases and treatments.
The atlas consists of two complementary datasets: Proteins expressed in multiple tissues are represented in the Protein Atlas Portal (MAP), which presents detailed information about their expression profiles across many organs and cell types.
Proteins that are only expressed in specific tissues or disease sites are presented in the Human Protein Atlas (HPA), where each protein is annotated with a single image-based entry page summarizing its subcellular localization, tissue distribution and functional classification.
Cell-based antibody mapping with in situ tissue analyses
The human protein atlas is a worldwide collaborative project that aims to map and characterize all protein coding genes from human tissues and cells. The main goal has been to combine cell-based antibody mapping with in situ tissue analyses, and correlate these data with different transcriptomic and proteomic data sets from the same cell type or tissue.
The Human Protein Atlas (HPA) is a community resource for proteomics research and education. The HPA provides public access to data on thousands of human proteins, including mRNA expression levels, antibodies and their target epitopes, as well as experimental methods used by the researchers who generated this data.
Human proteome
The Human Protein Atlas is a collection of data about the human proteome. It was originally developed at the European Bioinformatics Institute (EBI), with funding from the Wellcome Trust, as a resource for understanding protein structure and function in health and disease.
The Human Protein Atlas provides an integrated view of the human proteome based on data generated by different laboratories across the globe. The atlas contains information about gene expression, protein-protein interactions and post-translational modifications that have been collected from different resources into one place.
The Human Protein Atlas has four main goals:
- To provide an overview of human protein function, structure and interaction networks
- To link genomics with proteomics to identify genes linked to specific biological processes or disease phenotypes
- To provide tools for researchers to analyze large amounts of data more efficiently
Conclusion
The Human Protein Atlas, as the idea was conceived, is likely to be a long-term project. It’s helpful, though, that there are many players involved with this. While a large number of organizations and companies have mobilized to work on this project (80 entities in total), there is still much more that could be done. For example, the atlas could be vastly improved if it were better funded. And with more funding, other aspects could be improved too, like adding more protein structures on an ongoing basis.